The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 31251-41-9, 31251-41-9, Name is 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, SMILES is O=C1C2=CC=C(Cl)C=C2CCC3=CC=CN=C31, in an article , author is Yoshida, Yuka, once mentioned of 31251-41-9.
Solid-phase synthesis and bioactivity evaluation of cherimolacyclopeptide E
Cherimolacylopeptide E (1) is a cyclic hexapeptide isolated from the seeds of Annona cherimola. Peptide 1 reportedly exhibits potent cytotoxicity against KB cells (IC50 0.017 mu M). To confirm the structure and bioactivity of 1, we conducted a total synthesis of its proposed structure. The synthesis was accomplished via solid-phase peptide elongation and macrocyclization by employing Fmoc/OAll-protected amino acids on 2-Cl-trityl resin. NMR analysis revealed that synthetic 1 exists in two conformations in pyridine-d(5). As the spectroscopic data of the major conformer of synthetic 1 were consistent with those of natural 1, the structure of cherimolacyclopeptide E was confirmed to be 1. However, our synthetic 1 exhibited low cytotoxicity against KB cells (IC50 > 100 mu M). In contrast to previously-reported findings, our synthetic 1 exhibited little antibacterial activity against Escherichia coli.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem