Chemistry is an experimental science, COA of Formula: C12H10N2, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 13362-78-2, Name is (E)-1,2-Di(pyridin-4-yl)ethene, molecular formula is C12H10N2, belongs to pyridine-derivatives compound. In a document, author is Duan, Jindian.
Copper-Catalyzed [3+2] Annulation of 2-Arylidene-1,3-Indandiones with N-Acetyl Enamides for the Synthesis of Spiropyrrolines
A copper-catalyzed intermolecular [3+2] annulation of 2-arylidene-1,3-indandiones with N-acetyl enamides has been developed to assemble spirocyclic pyrrolines, which are important building blocks for organic synthesis and drug discovery. This heteroannulation protocol tolerates various functional groups and proceeds in good to excellent yields. Mechanistic studies reveal that the reactions might involve radical processes. 1-Pyrrolines are important core structural constituents of numerous naturally occurring compounds and pharmaceuticals.([1]) On the other hand, spiroindane-1,3-diones have been the focus of considerable attention due to their prevalence in many natural products that possess varied and extensive biological activities, which include antitumor, antibiotic,([2]) and antiproliferative activity on HL60 and apoptosis resistant leukemia cell lines. Accordingly, a number of synthetic strategies have been investigated to construct these skeletons. Considering the biomedical importance of the two classes of compounds, the introduction of spiroindane-1,3-dione group into the pyrroline core structure may further broaden the utilization of these compounds and potentially benefit drug-discovery efforts.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 13362-78-2, in my other articles. COA of Formula: C12H10N2.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem