Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Rawat, Deepa, once mentioned the application of 89-00-9, Name is Pyridine-2,3-dicarboxylic acid, molecular formula is C7H5NO4, molecular weight is 167.1189, MDL number is MFCD00006295, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Application In Synthesis of Pyridine-2,3-dicarboxylic acid.
Pd-Catalyzed ortho Selective C-H Acyloxylation and Hydroxylation of Pyridotriazoles
An efficient protocol for the palladium-catalyzed direct ortho C-H acyloxylation of 3-phenyl-pyridotriazoles is described. The reaction was facilitated by PhI(OAc)(2) (PIDA) as an oxidant and with carboxylic acids as acyloxylation reagents. The reaction is highly selective for mono acyloxylation of pyridotriazoles with various acids such as aliphatic, branched, and cyclic including adamantane carboxylic acids. When acetic anhydride was employed as acylation reagent, interesting 2-oxo-1-phenyl-1-(pyridin-2-yl)propyl acetates were obtained through the ring opening of pyridotriazoles. The key strategy is the employment of pyridotriazoles as a modifiable heterocycle; acyloxylation followed by the hydrolysis in one pot to yield the potential drug intermediates [(2-hydroxyphenyl)pyridin-2-yl]methanone in good yields.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem