Electric Literature of 80194-68-9 ,Some common heterocyclic compound, 80194-68-9, molecular formula is C7H3ClF3NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The third step: 0.24g2-(4-(methylthio)phenoxy)acetyl hydrazine and0.25g3-Chloro-5-trifluoromethylpicolinic acid added to the tube with a thermowellIn a 50 mL three-necked flask, 4 mL of POCl3 was added, the stirrer was turned on, and the mixture was heated and stirred, followed by heating to 100 C. The progress of the reaction was followed by TCL, and when it was detected that the starting point of the reaction system disappeared, the reaction was stopped.Post-treatment: The reaction solution was slowly introduced into a 250 mL beaker containing ice cubes, and the pH was adjusted to 9-10 with Na2CO3. A large amount of yellow solid was produced at the bottom of the beaker, suction filtered, washed with water several times to neutral, and dried. After separation and purification by column chromatography (P: E = 3:1), the title compound was obtained.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 80194-68-9, 3-Chloro-5-(trifluoromethyl)picolinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Guizhou University; Wu Jian; Xu Fangzhou; Wang Yanyan; Luo Dexia; Xue Wei; (37 pag.)CN108218848; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem