Synthetic Route of 170886-13-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 170886-13-2, name is 2-(Trifluoromethyl)pyridin-4-ol. A new synthetic method of this compound is introduced below.
A mixture of 2-(trifluoromethyl)pyridin-4-ol (100 mg, 0.613 mmol) and Lawesson?s reagent (123.99 mg, 0.307 mmol) in toluene (10 mL) was refluxed for 2 hours. Excess solvent was evaporated under reduced pressure. The residue was purified by automate column chromatography to give the desired product (75 mg, 68% yield). LC-MS: m/z: 180 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,170886-13-2, 2-(Trifluoromethyl)pyridin-4-ol, and friends who are interested can also refer to it.
Reference:
Patent; HELMHOLTZ-ZENTRUM FUeR INFEKTIONSFORSCHUNG GMBH; AHMED, Ahmed S. A.; EMPTING, Martin; HAMED, Mostafa; HARTMANN, Rolf W.; HAUPENTHAL, Joerg; HASTERKAMP, Thomas; KAMAL, Ahmed A. M.; MAURER, Christine K.; ROeHRIG, Teresa; SCHUeTZ, Christian; YAHIAOUI, Samir; ZENDER, Michael; (128 pag.)WO2020/7938; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem