Adding a certain compound to certain chemical reactions, such as: 93683-65-9, 6-Chloro-3-nitropicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 93683-65-9, blongs to pyridine-derivatives compound. Product Details of 93683-65-9
To a 1 L flask was added 2 (20.0 g, 108.8 mmol), 400 mL CH2Cl2,TBAB (16 g, 52 mmol) and a solution of rongalite (140.4 g /400 mL H2O) in proper order, the suspension wasstirred acutely at room temperature for 2 hours, after addition of another 75.2 g rongalite, the reaction mixturewas kept stirred for another 1.5 hours. After the reaction, the mixture was neutralized with saturated potassiumcarbonate and stirred for 30 minutes, then the mixture was poured into separator funnel and separated to obtainthe organic phase, the aqueous phase was extracted with CH2Cl2 (300 mL ×2), the organic phase was collectedand dried with MgSO4. After concentrating to saturate state, it was salified with hydrogen chloride saturated indiethyl ether. The white solid appeared was filtered, dissolved in water and precipitated absolutely with additionof aqueous ammonia. The mixture was filtered again to yield 14.6 g white solid (40%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,93683-65-9, its application will become more common.
Reference:
Article; Fan, Yin-Bo; Li, Kun; Huang, Min; Cao, Yu; Li, Ying; Jin, Shu-Yu; Liu, Wen-Bing; Wen, Jia-Chen; Liu, Dan; Zhao, Lin-Xiang; Bioorganic and Medicinal Chemistry Letters; vol. 26; 4; (2016); p. 1224 – 1228;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem