Adding a certain compound to certain chemical reactions, such as: 5398-44-7, 2,6-Dichloroisonicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5398-44-7, blongs to pyridine-derivatives compound. category: pyridine-derivatives
To a solution of 2,6-dichloroisonicotinic acid (10.0 g, 52.1 mmol) in THF (213 mL) at 0 0C was added dimethylaminopyridine (3.18 g, 26.0 mmol). A solution of di-tert-butyl dicarbonate (13.64 g. 62.5 mmol) in THF (20 mL) was added and the mixture was allowed to warm to ambient temperature. After 18 h, the solvent was removed and HCl (0.1 Nu aqueous solution) was added and the mixture was extracted with ethyl acetate (3x). The combined organic layer was washed with brine, dried over sodium sulfate, filtered and concentrated: LC-MS [M+l-16] = 233.0.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5398-44-7, its application will become more common.
Reference:
Patent; MERCK SHARP &; DOHME CORP.; BURGEY, Christopher, S.; DENG, Zhengwu, J.; NGUYEN, Diem, N.; PAONE, Daniel, V.; POTTEIGER, Craig, M.; STAUFFER, Shaun, R.; SEGERDELL, Carolyn; NOMLAND, Ashley; LIM, John, J.; WO2010/111058; (2010); A1;,
Pyridine – Wikipedia,
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