Adding a certain compound to certain chemical reactions, such as: 5654-97-7, 1,3-Dihydro-2H-pyrrolo[2,3-b]pyridin-2-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5654-97-7, blongs to pyridine-derivatives compound. Computed Properties of C7H6N2O
To a stirred solution of 7-Azaoxindole 1 (0.5 g ,3.73mmol ) in anhydrous THF(10 ml ) was added «-BuLi (0.47g,7.42 mmol)at -78 C followed by TMEDA(0.865 g, 7.42mmol ). After lh Mel( 0.876 g, 7.42 mmol) was added slowly and mixture was allowed to come up to room temperature. After stirring for lh , saturated aqueous ammonium chloride was added and the crude material was partitioned between water and ethyl acetate. Organic layer was separated, dried over sodium sulphate and concentrated under vacuum. Crude compound was purified by column chromatography by eluting with 40% ethyl acetate in pet ether to get the desired compound 2 (0.1 g)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5654-97-7, its application will become more common.
Reference:
Patent; VITAS PHARMA RESEARCH PRIVATE LIMITED; RANGARAJAN, Radha; KUMAR, Rajinder; PRABHAKAR, B V; CHANDRASEKHAR, P; MALLIKARJUNA, P; BANERJEE, Ankita; WO2013/42035; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem