If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 84539-30-0, 5-Bromo-N-methylpyridin-2-amine.
Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 84539-30-0, name is 5-Bromo-N-methylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H7BrN2
a) tert-butyl 5-methoxy-2-[6-(methylamino)pyridin-3-yl]-lH-indole-l-carboxylate l-(tert-Butoxycarbonyl)-5-methoxyindole-2-boronic acid (2 mmol), 5-bromopyridine-2- methylamine (2 mmol), Pd(dppf)Cl2 (0.10 mmol) and 2M Na2CO3 (aq.) (3 mL) were mixed in THF/water 5:1 (10 mL) in a 20 mL microwave vial. The reaction mixture was stirred at 1200C in the microwave reactor for 15 min. Water was added and the solution was extracted with EtOAc. The organic extracts were dried over Na2SO4, filtered and concentrated. The crude mixture was purified by flash chromatography (Heptane/EtOAc gradient) to afford the title intermediate (256 mg). 1H NMR delta ppm 8.04 (d, 1 H) 7.94 (d, 1 H) 7.43 (dd, 1 H) 7.08 (d, 1 H) 6.89 (dd, 1 H) 6.64 (d, 1 H) 6.53 (s, 1 H) 6.50 (d, 1 H) 3.78 (s, 3 H) 2.80 (d, 3 H) 1.36 (s, 9 H); MS m/z (M+H) 354.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 84539-30-0, 5-Bromo-N-methylpyridin-2-amine.
Reference:
Patent; ASTRAZENECA AB; WO2008/108729; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem