Adding a certain compound to certain chemical reactions, such as: 67515-76-8, Methyl 5-aminopicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
N-Bromosuccinimide (468 mg, 2.63 mmol) was added portion-wise to a 50 o solution of methyl 5-aminopyridine-2-carboxylate (400 mg, 2.6 mmol) in acetonitrile (15 mL), and the reaction mixture was heated at 50 00 overnight. Crude reaction mixtures from six additional small-scale reactions of this transformation were added (total starting material quantity: 760 mg, 5.0 mmol), and the resulting mixture was concentrated invacuo, then purified via silica gel chromatography (Gradient: 2% to 66% ethyl acetate in petroleum ether), providing the product as a red solid. Yield: 150 mg, 0.65 mmol, 13%. 1H NMR (400 MHz, CDCI3) oe 8.23 (5, 1H), 8.16 (5, 1H), 4.61 (brs, 2H), 3.97 (5, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,67515-76-8, Methyl 5-aminopicolinate, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER INC.; BRODNEY, Michael Aaron; DAVOREN, Jennifer Elizabeth; GARNSEY, Michelle Renee; ZHANG, Lei; O’NEIL, Steven Victor; (174 pag.)WO2016/9297; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem