Synthetic Route of 1214353-79-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1214353-79-3, name is Methyl 5-bromo-6-chloropicolinate. This compound has unique chemical properties. The synthetic route is as follows.
Methyl 5-bromo-6-chloropyridine-2-carboxylate (Ark Pharm, 360 mg, 1.4 mmol), copper(I) iodide (19 mg, 0.10 mmol) and dichloro[bis(triphenylphosphonio)]palladate (60 mg, 0.086 mmol) were placed in a vial. The vial was then evacuated and backfilled with nitrogen three times. After this 1,4-dioxane (6.2 mL) and triethylamine (300 L, 2.16 mmol) were added. The reaction was stirred for 5 min. Then (trimethylsilyl)acetylene (244 muIota_,, 1.72 mmol) was added and the resulting reaction mixture was stirred at 60 C for 3 h. After this time the reaction was quenched with water and product was extracted with EtOAc. The combined organic fractions were washed with brine, dried with a2S04 and solvent was evaporated under reduced pressure. The crude product was purified by chromatography on silica gel using Biotage Isolera apparatus to give the sub-title compound (370 mg, 97%). LCMS calc. for C12H15CINO2S1 (M+H)+ m/z = 268.1; found: 268.0.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1214353-79-3, Methyl 5-bromo-6-chloropicolinate.
Reference:
Patent; INCYTE CORPORATION; VECHORKIN, Oleg; LI, Yun-Long; ZHU, Wenyu; (232 pag.)WO2016/10897; (2016); A1;,
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