Adding a certain compound to certain chemical reactions, such as: 108279-89-6, 2-Chloro-4,6-dimethoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 108279-89-6, blongs to pyridine-derivatives compound. Application In Synthesis of 2-Chloro-4,6-dimethoxypyridine
REFERENTIAL EXAMPLE 1 Synthesis of 2-(4,6-dimethoxypyrimidin-2-yloxy)-benzaldehyde (intermediate) After 2.2 g of salicylaldehyde were dissolved in 100 ml of dimethylformamide, 4.0 g of 60% sodium hydride were added little by little. The resulting mixture was stirred at room temperature for a while and, after foaming subsided, 17.5 g of 2-chloro-4,6-dimethoxypyridine were added, followed by heating to 100 C. After the mixture was stirred for 3 hours at the same temperature, dimethylformamide was recovered under reduced pressure. The residue was isolated by column chromatography on a silica gel and then eluted with a 7:3 mixed solvent of n-hexane and ethyl acetate, whereby 14.8 g of the target compound, 2-(4,6-dimethoxypyrimidine-2-yloxy)benzaldehyde, were obtained as crystals (m.p.: 96-98 C.; yield: 56.9%). IR (KBr) cm-1: 2720, 1710. NMR (400 MHz, CDC;3) delta from TMS: 3.80(6H,s), 5.81(1H,s), 7.27(1H,m), 7.36(1H,m), 7.64(1H,m), 7.95(1H,m), 10.24(1H,s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108279-89-6, its application will become more common.
Reference:
Patent; Mitsui Toatsu Chemicals, Inc.; US5178662; (1993); A;,
Pyridine – Wikipedia,
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