Related Products of 13143-47-0 ,Some common heterocyclic compound, 13143-47-0, molecular formula is C11H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
In a 100 mL round-bottomed flask, di(lH-imidazol-1-yl)methanethione (718 mg, 4.03 mmol, Eq:1.5) was combined with CH2Ch (30 mL) to give a colorless solution. 1-(4- Aminophenyl)pyridin-2(1H)-one (500 mg, 2.69 mmol, Eq: 1.00) in CH 2Ch (20 mL) was added dropwise at ooc. The reaction was allowed to warm to room temperature, and allowed to stirovernight. Concentrate the solution, the compound was isolated by column chromatography(Hexanes/EtOAc = 80/20) to give the product 580 mg (95% ). MH+228.9
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13143-47-0, 1-(4-Aminophenyl)-1H-pyridin-2-one, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BERTHEL, Steven Joseph; CHEN, Zhi; CHI, Feng; CHIN, Elbert; ERICKSON, Shawn David; GABRIEL, Stephen Deems; KOCER, Buelent; Mertz, Eric; PLANCHER, Jean-Marc; WEIKERT, Robert James; WO2014/135471; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem