Adding a certain compound to certain chemical reactions, such as: 13362-28-2, 2-Amino-4-pyridinecarboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H6N2O2, blongs to pyridine-derivatives compound. Computed Properties of C6H6N2O2
300 mg of 2-aminoisonicotinic acid (II-1) (2.172 mmol, 1 eq) was weighed into a 25 mL round bottom flask.Add 4 mL of methylene chloride and add 335 muL of anhydrous DMF (4.344 mmol, 2 eq).After stirring, 370 muL of oxalyl chloride (4.344 mmol, 2 eq) was added dropwise, and the mixture was stirred at room temperature for 30 minutes,The solution is light pink. Followed by the addition of p-methoxyaniline (2.606 mmol, 1.2 eq)And stirred at room temperature for 1.5 hours. The solution was light brown and white smoke was generated.525 mul of pyridine (6.516 mmol, 3 eq) and 2 mL of dichloromethane were added to the ice bath,Followed by stirring at room temperature for 30 minutes, the solution turned black and then turned orange, with bubbles generated.The solvent was dried to give a pale red solid which was added 5 mL of ethanol and 655 muL of ethylenediamine(9.774 mmol, 4.5 eq), heated and refluxed for 30 minutes. TLC detection reaction is completed,Stop heating, cooling directly after filtration, water and ether several times to clean the filter cake, infrared light drying,To give 399 mg of a pale yellow solid,2-amino-N- (4-methoxyphenyl) isonicotinamide (III-1) in a yield of 75.5%.
The synthetic route of 13362-28-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; China Pharmaceutical University; Sun Hongbin; Xin Tao; Wen Xiaoan; Wu Yizhou; Yuan Haoliang; (14 pag.)CN106632021; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem