Application of 1214334-70-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1214334-70-9, name is 5-Bromo-6-methoxypicolinic acid. This compound has unique chemical properties. The synthetic route is as follows.
5-bromo-6-methoxypicolinic acid (5 g, 22 mmol) was dissolved in DMF (50 mL) and cooled to 0C under argon. DIPEA (7.66 mL, 44 mmol), ammonium chloride (1.77 g, 33 mmol) and HATU (12.6 g, 33 mmol) were added and the mixture was warmed to room temperature and stirred overnight. Water (50 mL) was added and the solid precipitate 5-bromo-6-methoxypicolinamide was collected by filtration(4.21 g, 83%). ?H NMR (DMSO, 400 MHz): 8.14 (d, 1H), 8.04 (br s, 1H), 7.71 (br s, 1H), 7.48 (d, 1H), 4.00 (s, 3H). LCMS (basic, 3.1 mm): RT 1.64 mi [MHj+ 232.9, purity 83%.
According to the analysis of related databases, 1214334-70-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; FORUM PHARMCEUTICALS INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; MCRINER, Andrew, J.; (451 pag.)WO2016/201168; (2016); A1;,
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