Electric Literature of 1174229-72-1 ,Some common heterocyclic compound, 1174229-72-1, molecular formula is C9H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of ethyl 2-(6-aminopyridin-3-yl)acetate (1.7 g, 9.4 mmol) in t-BuOH (25was added TEA (1.1 g, 11.3 mmol) and (Boc)20 (2.5 g, 11.3 mol). The mixture was stirred at 50 C for 3h and then the reaction mixture was concentrated and the residue was purified by column chromatography (silica gel, PE : EtOAc = 10 : 1) to give ethyl 2-(6-((tert-butoxy- carbonyl)amino)pyridin-3-yl)acetate (1.9 g, 73%) as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1174229-72-1, Ethyl 2-(6-aminopyridin-3-yl)acetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PRINCIPIA BIOPHARMA INC.; BRAMELD, Kenneth A.; VERNER, Erik; WO2014/182829; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem