With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.128071-75-0, name is 2-Bromonicotinaldehyde, molecular formula is C6H4BrNO, molecular weight is 186.01, as common compound, the synthetic route is as follows.COA of Formula: C6H4BrNO
General procedure: In a 20 mL glass tube equipped with septa, the aldehyde, dry Na2SO4 (2.81 equiv) and triethylamine (2 equiv) were suspended in dry THF. Then, the hydroxylamine hydrochloride (2 equiv) was added. The mixture was stirred for 30 s, and then exposed to MWI (250 W) at 80 C during the time indicated for each compound. When the reaction was(TLC analysis), the reaction mixture was diluted with water, extracted with CH2Cl2, driedanhydrous sodium sulphate, filtered and the solvent was evaporated. The resultant solid was purified by column chromatography to give pure compounds.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,128071-75-0, 2-Bromonicotinaldehyde, and friends who are interested can also refer to it.
Reference:
Article; Samadi, Abdelouahid; Soriano, Elena; Revuelta, Julia; Valderas, Carolina; Chioua, Mourad; Garrido, Ignacio; Bartolome, Begona; Tomassolli, Isabelle; Ismaili, Lhassane; Gonzalez-Lafuente, Laura; Villarroya, Mercedes; Garcia, Antonio G.; Oset-Gasque, Maria J.; Marco-Contelles, Jose; Bioorganic and Medicinal Chemistry; vol. 19; 2; (2011); p. 951 – 960;,
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