With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.176690-44-1, name is 2-(Pyridin-3-yl)benzaldehyde, molecular formula is C12H9NO, molecular weight is 183.21, as common compound, the synthetic route is as follows.Recommanded Product: 2-(Pyridin-3-yl)benzaldehyde
To a solution of 2-pyridin-3-yl-benzaldehyde (1 g, 5.46 mmole) in methanol (10 ml) was added a solution of NaBH4 (0.26 g, 6.82 mmole) in methanol (10 ml) at 0 C and stirred for 30 min at same temperature and then refluxed for 1 h. The unreacted NaBH4 was decomposed by solution of 6N HCI. The solvent was removed under reduced pressure and the residue was dissolved in 5N NaOH (20 ml) and extracted with ethyl acetate (3X20 ml). Combined organic extracts were dried (Na2S04), filtered and concentrated to yield 0.95 g (94%) of product. MS (ESI+) m/z 186 (M+H) +.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,176690-44-1, 2-(Pyridin-3-yl)benzaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; ABBOTT LABORATORIES; LI, Tongmei; WO2005/111003; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem