Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 620-08-6, name is 4-Methoxypyridine. A new synthetic method of this compound is introduced below., Computed Properties of C6H7NO
a) Preparation of Intermediate 21 Di-tert-butyl dicarbonate (58.333 mmol) was added portionwise under a N2 atmosphere and with rapid stirring to a solution of 4-methoxypyridine (58.333 mmol) in THF (60 ml). The mixture was cooled to 0 C., vinylmagnesium bromide (70 mmol) was added dropwise and the mixture was stirred for 3 hours at room temperature. HCl (1N) (about 150 ml) was added at 5 C. (ambient temperature of 25 C.) and the mixture was stirred for 10 minutes. The mixture was extracted with EtOAc. The organic layer was washed with 10% aqueous NaHCO3 solution then brine, dried over MgSO4, filtered and evaporated to dryness, yielding 10.7 g (82.1%) of intermediate 21.
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Reference:
Patent; Guillemont, Jerome Emile Georges; Motte, Magali Madeleine Simone; Lancois, David Francis Alain; Thomas, Sebastein Robert Gaston; Balemans, Wendy Mia Albert; US2015/51244; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem