The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 777899-57-7, name is Methyl 2-chloro-5-nitroisonicotinate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H5ClN2O4
The starting material of tert-butyl ethyl malonate (41.7 g, 222 mmol, 1.2 eq.) was dissolved in anhydrous DMF (100 mL), cooled to 0 C, and stirred for 0.5 h. NaH (14.8 g, 370 mmol, 2 eq.) was added. After stirring for 0.5 h, methyl 2-chloro-5-nitroisonicotinate (40.0 g, 185 mmol, 1.0 eq.) was slowly added and stirred at room temperature for 5 h. The reaction was completely monitored by TLC, quenched with water at 0 C, concentrated, and extracted with EA (3×500 mL). The filtrate was concentrated under reduced pressure and the crude product was purified by silica gel column chromatography (PE: EA = 10: 1) to give the purified product (35g, yield: 51.4%).
With the rapid development of chemical substances, we look forward to future research findings about 777899-57-7.
Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; Yang Xiaoju; (118 pag.)CN109575016; (2019); A;,
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