Synthetic Route of 74976-31-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74976-31-1, name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine. This compound has unique chemical properties. The synthetic route is as follows.
Into a 100 mL 3-necked round-bottom flask was added a solution of 6-chloro- lH-pyrrolo [3, 2- c]pyridine (1.00 g, 6.55 mmol) in N,N-dimethylformamide (10 mL), potassium hydroxide (1.40 g, 24.9 mmol). The reaction mixture was stirred for 20 min at room temperature, then I2 (1.66 g, 6.54 mmol, 1.00) was added to the solution. The reaction mixture was stirred for additional 30 min at room temperature. The reaction mixture was diluted with H20 (50 mL) and the solids were collected by filtration. The solids were dried under reduced pressure overnight to afford 6-chloro- 3-iodo-lH-pyrrolo[3,2-c]pyridine (1.70 g, 93.0%) as a yellow solid. LCMS (ESI): RT (min) = 1.321, [M+H]+ = 279, method = N.
According to the analysis of related databases, 74976-31-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; HANAN, Emily; HEFFRON, Timothy; PURKEY, Hans; ELLIOTT, Richard Leonard; HEALD, Robert; KNIGHT, Jamie; LAINCHBURY, Michael; SEWARD, Eileen M.; WO2014/81718; (2014); A1;,
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