Application of 73583-39-8, Adding some certain compound to certain chemical reactions, such as: 73583-39-8, name is 3-Bromo-5-chloropyridine,molecular formula is C5H3BrClN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 73583-39-8.
Diacetoxypalladium (40.5 mg, 0.181 mmol) and di(adamantan-l-yl)-(butyl)phosphine (129 mg, 0.361 mmol) in DMA (3 ml) was degassed for two minutes and stirred at RT under N2 for 15 minutes. Under N2, a mixture of (S)-iert-butyl 3-((9-ethyl-9H-purin-6-yl)amino)pyrrolidine-l- carboxylate (300 mg, 0.90 mmol), 3-bromo-5-chloropyridine (521 mg, 2.71 mmol), pivalic acid (138 mg, 1.35 mmol) and potassium carbonate (575 mg, 2.71 mmol) was added to the catalyst mixture at RT. The reaction mixture was then degassed with N2 and the mixture was heated to 130 °C with stirring for 16h. The reaction mixture was then cooled and filtered. The solids were washed with ethyl acetate and the combined filtrates were concentrated in vacuo. The residue was purified by column chromatography on silica gel Isolute Flash Si; 10 g pre-packed, eluting with EtOAc:hexanes (3: 1) to give the title compound. MS (ESI) calc’d for (C21H27CIN7O2) [M+H]+, 444 ; found, 444
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 73583-39-8, 3-Bromo-5-chloropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; ACHAB, Abdelghani Abe; ALTMAN, Michael D.; DENG, Yongqi; KATTAR, Solomon; KATZ, Jason D.; METHOT, Joey L.; ZHOU, Hua; MCGOWAN, Meredeth; CHRISTOPHER, Matthew P.; GARCIA, Yudith; ANTHONY, Neville John; FRADERA LLINAS, Francesc Xavier; YANG, Liping; MU, Changwei; WANG, Xiaona; SHI, Feng; YE, Baijun; ZHANG, Sixing; ZHAO, Xiaoli; ZHANG, Rong; FONG, Kin Chiu; LENG, Xiansheng; WO2014/75393; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem