With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1594-57-6, name is N-Hydroxyisonicotinimidamide, molecular formula is C6H7N3O, molecular weight is 137.14, as common compound, the synthetic route is as follows.COA of Formula: C6H7N3O
Preparation 3: trans-4- (3-Pyridin-4-yl- [1, 2,4] oxadiazol-5-yl) cyclohexanecarboxylic acid methyl ester A solution of cyclohexane-1, 4-dicarboxylic acid monomethyl ester (1.053g, 5.66mmol) and triethylamine (800gel, 5. 66mmol) in toluene (30ml) was cooled to 0C and isobutylchloroformate (735} il, 5. 66mmol) introduced dropwise. The mixture was stirred at rt for 30min whereupon activated, powdered 3A molecular sieves (5g) and N- hydroxyisonicotinamidine (705mg, 5.14mmol) were added. The mixture was heated under reflux for 18h, cooled and filtered through celite. The solvent was removed in vacuo and the residue purified by flash chromatography (IH-EtOAc, 1: 1) to afford the title compound: RT = 3. 20min ; m/z (ES) = 288. 2 [M+H] +.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1594-57-6, N-Hydroxyisonicotinimidamide, and friends who are interested can also refer to it.
Reference:
Patent; PROSIDION LIMITED; WO2005/61489; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem