Adding a certain compound to certain chemical reactions, such as: 103-74-2, 2-(2-Hydroxyethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H9NO, blongs to pyridine-derivatives compound. Computed Properties of C7H9NO
Example 15l-(2-Chlorophenyl)-4-methyl-8-(2-pyridin-2-ylethoxy)[l,2,4]triazolo[4,3- a]quinoxaline (B-15)A mixture of compound B-13 (1.5 g, 4.83 mmol), 2-(2-hydroxyethyl)pyridine (0.654 mL, 5.79 mmol), di-tert-butylazadicarboxylate (1.33 g, 5.79 mmol) andtriphenylphosphine (1.52 g, 5.79 mmol), in THF (36 mL) was heated in a microwave oven for 20 min at 120 C (the reaction mixture was divided in three batches). Then 1 equiv. more of di-tert-butylazadicarboxylate and triphenylphosphine were added and the r.m. was heated again at the same conditions as before. Then the solvent was evaporated, the crude compound taken up in aq. sat. NaHC03 and then extracted with DCM. The organic layer was separated, dried (Na2S04), filtered and the solvent concentrated in vacuo. The crude mixture was purified by chromatography (silica, MeOH in EtOAc 0: 100 to 15:85) to give an oil that was made solid by addition of diethylether to yield final product B-15 as white solid (1.32 g, 65.7%). 1H NMR (500 MHz, CDCls) delta ppm 3.04 (s, 3 H), 3.14 (t, J=6.8 Hz, 2 H), 3.91 – 4.05 (m, 2 H), 6.67 (d, J=2.6 Hz, 1 H), 7.11 (dd, J=9.2, 2.6 Hz, 1 H), 7.17 (d, J=8.4 Hz, 1 H), 7.18 – 7.24 (m, 1 H), 7.48 – 7.54 (m, 2 H), 7.56 – 7.61 (m, 1 H), 7.64 (td, J=7.7, 1.9 Hz, 1 H), 7.68 (dd, J=5.9, 3.3 Hz, 1 H), 7.92 (d, J=9.0 Hz, 1 H), 8.57 (d, J=4.3 Hz, 1 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,103-74-2, 2-(2-Hydroxyethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; ANDRES-GIL, Jose, Ignacio; ROMBOUTS, Frederik, Jan, Rita; TRABANCO-SUAREZ, Andres, Avelino; VANHOOF, Greta, Constantia, Peter; DE ANGELIS, Meri; BUIJNSTERS, Peter, Jacobus, Johannes, Antonius; GUILLEMONT, Jerome, Emile, Georges; BORMANS, Guy, Maurits R.; CELEN, Sofie, Jeanne, Leopoldine; VLIEGEN, Maarten; WO2013/924; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem