Electric Literature of 6313-54-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6313-54-8, name is 2-Chloroisonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.
Thionyl chloride (20 ml) was added to 2-chloroisonicotinic acid (1.2 g) at room temperature. DMF (2 drops) was added and the mixture was heated to reflux for 1 hour. The excess thionyl chloride was evaporated and the residue was dissolved in dichloromethane (50 ml). Triethylamine (2 ml) was added followed by dropwise addition of a solution of spiro [indoline- 3, [4′-PIPERIDINE]-1′-CARBOXYLIC] acid tert-butyl ester (1.7 g) dissolved in dichloromethane (20 ml). The mixture was stirred for 48 hours. The reaction mixture was washed with pH 9.4 buffer (100 ml) and the aqueous layer was extracted with dichloromethane. The combined organic layers were dried (magnesium sulfate), filtered and evaporated. The crude product was purified by chromatography [[SI02] ; ethyl acetate-hexane-triethylamine (50: 50: 1), increasing polarity to (100: 0: 1) ] to give 2.4 g (94%) of the desired amide. M. p. [212 C ;’H] NMR (400 MHz, d6- DMSO) 1.50 (s, 9H), 1.6-1. 8 [(M,] 4H), 2.8 (br s, 2H), 3.9 (br s, 2H), 4.08 (d, 2H), 7.0-7. 2 (m, 3H), 7.30 (d, J = 6Hz, [1H),] 8.43 (d, J = 6Hz, [1H),] 7.40 (s, [1H),] 8.0-8. 2 (br [M, 1H)] ; MS (ES+) 428/430 [(M+H+),] 372/374 (M+H+-isobutene).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6313-54-8, 2-Chloroisonicotinic acid.
Reference:
Patent; SYNGENTA LIMITED; SYNGENTA PARTICIPATIONS AG; Hughes, David, John; Worthington, Paul, Anthony; Russell, Charles, Adam; Ckarke, Eric, Daniel; Peace, James, Edward; Ashton, Mark, Richard; Coulter, Thomas, Stephen; Roberts, Richard, Spurring; Molleyres, Louis-Pierre; Cederbaum, Fredrik; Cassayre, Jerome; Maienfisch, Peter; WO2003/106457; (2003); A1;,
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