Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6265-73-2, name is N-(2-Hydroxyethyl)nicotinamide. A new synthetic method of this compound is introduced below., Safety of N-(2-Hydroxyethyl)nicotinamide
General procedure: A4 (100mg, 0.6mmol) was combined with 2-chloro-4-nitrophenyl isothiocyanate (129mg, 0.6mmol) in anhydrous THF (30mL) at 0C, followed by the addition of DBU (106mg, 0.7mmol). The resultant mixture was stirred at 0C for 20min, after which the ice bath was removed, and the reaction mixture was stirred at room temperature until the completion of the reaction indicated by TLC. The crude product was purified by column chromatography (chloroform/methanol, 30/1).
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Reference:
Article; Bai, Zhongjie; Zhang, Jinlong; Zhang, Qiuping; Wang; Li, Jili; Zhao, Quanyi; Wang, Zhen; He, Dian; Zhang, Jingke; Liu, Bin; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3307 – 3318;,
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