In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 76006-13-8, name is 3-Bromo-1H-pyrazolo[3,4-c]pyridine, the common compound, a new synthetic route is introduced below. Safety of 3-Bromo-1H-pyrazolo[3,4-c]pyridine
ii) Preparation of 3-bromo-1-(2-chloro-6-(trifluoromethyl)benzyl)-1H-pyrazolo[4,3-b]pyridine (A-4) A mixture of 2-chloro-6-(trifluoromethyl)benzyl 4-methylbenzenesulfonate (A-2) (0.19 g, 0.51 mmol), 3-bromo-1H-pyrazolo[3,4-c]pyridine (A-3) (0.1 g, 0.51 mmol), t-BuOK (0.11 g, 1.02 mmol) and TBAI (75 mg, 0.20 mmol) in THF (5 ml) was heated at 60 C. for 14 h. The reaction mixture was cooled down, diluted with saturated NH4Cl solution (20 ml) and extracted with ethyl acetate (30 ml*2). The combined organic layers were washed with brine (20 ml), dried over anhydrous Na2SO4 and concentrated to give the title compound A-4 as a brown oil. LCMS (ESI) calc’d for C14H8BrClF3N3 [M+H]+: 390. found: 390.
The synthetic route of 76006-13-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Barr, Kenneth J.; Bienstock, Corey E.; MacLean, John K.; Zhang, Hongjun; Beresis, Richard T.; Anthony, Neville J.; Lapointe, Blair T.; Sciammetta, Nunzio; US2015/210687; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem