Application of 845827-15-8, Adding some certain compound to certain chemical reactions, such as: 845827-15-8, name is Methyl [2,3′-bipyridine]-6′-carboxylate,molecular formula is C12H10N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 845827-15-8.
2,3′-Dipyridine-6′-carboxylic acid (1) Conducting the operations similar to those of Production Example 14 using 2-iodopyridine and 6-bromo-3-pyridineboronic acid, 6′-bromo-2,3′-dipyridine was obtained. (2) The compound (330 mg) as obtained in above (1), catalytic amount of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium and triethylamine (0.7 ml) were added to a DMF-methanol mixed solution (DMF/methanol; 5/1 ml) and stirred in carbon monoxide atmosphere at 80C for a day and night, to provide methyl-2,3′- dipyridine-6′-carboxylate (160 mg). Hydrolyzing this with 5N aqueous sodium hydroxide solution, the title compound (110 mg) was obtained as white solid. ESI-MS Found:m/z 201 [M+H]+
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Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1657242; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem