Some tips on 5-Chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,800401-68-7, its application will become more common.

Electric Literature of 800401-68-7 ,Some common heterocyclic compound, 800401-68-7, molecular formula is C8H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 11: 5-Chloro-lH-pyrrolo[2,3-c]pyridine-2-carboxylic acid; (7-fluoro-2-oxo-l,2,3,4- tetrahydroquinolin-3-yl)amide To a suspension of 3-amino-7-fluoro-3,4-dihydro-lH-quinolin-2-one hydrochloride(Preparation 35, lOOmg, 0.4mmol) in anhydrous THF (5mL) was added DMTMM (349mg, 1.19mmol) and 4-methyl morpholine (130muL, 1.19mmol), followed by 5-chloro-lH-pyrrolo[2,3- c]pyridine-2-carboxylic acid (Preparation 3, 71mg, 0.36mmol), and the reaction stirred at rt for 16h. Solvent was concentrated in vacuo and the residue taken into EtOAc (5OmL). Organics were washed EPO with water (3OmL), IM HCl (3OmL) and brine (3OmL) before being dried (MgSO4) and removing the solvent in vacuo. Trituration from methanol afforded the title compound. deltaH(d6 DMSO): 12.35 (IH, s), 10.50 (IH, s), 9.07 (IH, d), 8.59 (IH, s), 7.78 (IH, s), 7.33-7.20 (2H, m), 6.83-6.64 (2H, m), 4.83-4.71 (IH, m), 3.11 (2H, d); m/z (ES+) = 359.06 [M+ H]+; RT = 3.44min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,800401-68-7, its application will become more common.

Reference:
Patent; PROSIDION LIMITED; WO2006/59164; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem