Application of 1018949-67-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1018949-67-1 as follows.
General procedure: In a three neck round bottom flask (50 mL in volume) along with guard tube was charged with carboxylic acid (1.0 equiv) in 5 ml solvent combination of CH2Cl2: DMF (4:1). After few minutes stirring at room temperature the resulting suspension was cooled with an ice-water bath prior to the addition of the bis(2-oxo-3-oxazolidinyl)phosphonic chloride (1.5 equiv) and the starting compound 1a (1.0 equiv). The resulting mixture was stirred again for few minutes and then DIPEA (3.0 equiv) was added. The mixture was kept at 0 C for 30-60 min and then stirred at room temperature until the starting material was consumed as monitored by TLC analysis. Ice-water (20 mL) was added while maintaining vigorous stirring. In the cases when the indole precipitated upon addition of water, the solid was filtered off and dissolved in EtOAc (20 mL). In all other cases, the aqueous layer was extracted with EtOAc (3 × 20 mL). The extracts were combined and washed with water (2 × 50 mL). The organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. The residue was purified either by silica gel chromatography.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1018949-67-1, its application will become more common.
Reference:
Article; Jadhav, Jagannath; Khanapaure, Sharanabasappa; Kurane, Rajanikant; Salunkhe, Rajashri; Rashinkar, Gajanan; Tetrahedron Letters; vol. 54; 50; (2013); p. 6858 – 6863;,
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