Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 119285-07-3, name is tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate
4-(5-Amino-pyridin-2-yl)-piperazine-l-carboxylic acid tert-butyl ester (1.5 g), 3-Chloro- benzo[l,2,4]triazine 1 -oxide (1.2 g) and DMF (20 ml) and potassium carbonate (1.5 g) were heated to 50-60 C and stirred over night. On completion, water (200 ml) was added and extracted with ethyl acetate (2×200 ml). The combined organic extracts were dried over sodium sulfate. The solvent was removed under reduced pressure to give a residue, which was further purified by column chromatography (SiO2, 25% EtOAc/n-hexane) to yield 4-[5-(l-Oxy- benzo[l,2,4]triazin-3-ylamino)-pyridin-2-yl]-piperazine-l-carboxylic acid tert-butyl ester.
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Reference:
Patent; SENTINEL ONCOLOGY LIMITED; WO2006/131835; (2006); A2;,
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