Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1187236-18-5, name is Ethyl 7-bromoimidazo[1,2-a]pyridine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Safety of Ethyl 7-bromoimidazo[1,2-a]pyridine-2-carboxylate
To a suspension of ethyl 7-bromoimidazo[l,2-a]pyridine-2-carboxylate (3.50 g, 13.0 mmol) in anhydrous DCM (80 mL) was added diisobutyl aluminum hydride (18.50 mL, 18.50 mmol, 1.0 M) at -78 C under N2 atmosphere. The mixture was stirred at -78 C overnight and then moved to 0 C, and quenched with water (0.75 mL), 15% NaOH aqueous solution (0.75 mL) and another water (2 mL) successively. The resulting mixture was stirred at rt for 15 min. To the mixture were added Et20 (50 mL), EtOAc (50 mL) and hydrous Mg2S04 (20 g), stirred for 15 min, filtered. The filter cake was washed with EtOAc (200 mL), the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/PE (v/v) = 1/10 to 1/5) to afford the title compound as a light-yellow solid (1.50 g, 51%).MS (ESI, pos. ion) m/z: 225.0 [M+H]+;1H NMR (400 MHz, CDCl3) d (ppm): 10.14 (s, 1H), 8.13 (s, 1H), 8.04 (d, J= 7.2 Hz, 1H), 7.89 (s, 1H), 7.02 (dd, j= 7.2, 1.7 Hz, 1H).
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Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; XI, Ning; LI, Minxiong; PENG, Ju; LI, Xiaobo; ZHANG, Tao; HU, Haiyang; CHEN, Wuhong; BAI, Changlin; KE, Donghua; CHEN, Peng; (281 pag.)WO2019/99311; (2019); A1;,
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