Related Products of 19337-97-4 ,Some common heterocyclic compound, 19337-97-4, molecular formula is C8H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a mixture of (E)-3-(pyridin-3-yl)acrylic acid (37 mg, 0.25 mmol) in DMF (2 mL) was added EDCI (78 mg, 0.41mmol), HOBt (41 mg, 0.31 mmol), triethylamine (0.06mL, 0.41mmol), and compound 40a (65 mg, 0.2 mmol), and the reaction mixture was stirred for 4 h at room temperature. DMF was evaporated under reduced pressure. The residue was extracted with ethyl acetate (4 mL × 3). The combined organic layers were washed with saturated aqueous NaHCO3 solution, saturated aqueous NH4Cl solution and brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The resulting mixture was purified by silica column chromatography to give the target compound 19 as white solid (45 mg, 50percent). 1H NMR (400 MHz, CDCl3) delta 8.76 (s, 1H), 8.57 (d, J = 4.2 Hz, 1H), 7.81 (d, J = 8.0 Hz, 1H), 7.65 (d, J = 15.7 Hz, 1H), 7.60 (s, 1H), 7.52 (s, 1H), 7.30 (t, J = 9.1 Hz, 3H), 7.23 (d, J = 7.7 Hz, 3H), 7.12 (d, J = 6.5 Hz, 3H), 6.47 (d, J = 15.7 Hz, 1H), 5.78 (s, 1H), 3.37 (dd, J = 13.2, 6.8 Hz, 2H), 2.63 (t, J = 7.3 Hz, 2H), 1.60 ? 1.52 (m, 4H), 1.30 (dt, J = 15.4, 7.6 Hz, 2H). 13C NMR (125 MHz, CDCl3) delta 165.4, 150.3, 149.1, 143.5, 139.1, 137. 7, 136.9, 134.6, 133.1, 130.7, 129.3, 128.9, 127.0, 125.4, 124.7, 123.8, 122.7, 122.1, 39.7, 35.1, 30.2, 29.3, 25.9. HRMS(ESI) m/z calculated for C25H28N3O3S [M + H]+: 450.1846, found 450.1846.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 19337-97-4, trans-3-(3-Pyridyl)acrylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Zhang, Kuojun; Ni, Yong; Chen, Jiaxuan; Tu, Zhengchao; Wu, Xiaoxing; Chen, Dong; Yao, Hequan; Jiang, Sheng; Bioorganic and Medicinal Chemistry Letters; vol. 29; 12; (2019); p. 1502 – 1506;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem