Adding a certain compound to certain chemical reactions, such as: 39891-13-9, 2-(6-Chloropyridin-3-yl)acetic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 39891-13-9, blongs to pyridine-derivatives compound. Quality Control of 2-(6-Chloropyridin-3-yl)acetic acid
To a stirred solution of 329 2-(6-chloropyridin-3-yl)acetic acid (10 g, 58.3 mmol) in 6 DCM (100 mL) and 139 MeOH (50 mL) was added 330 ((trimethylsilyl)methyl)diazene (8.3 mL, 175 mmol) at 0 C. The reaction was stirred at RT for 16 h and then the solvent was concentrated under reduced pressure. The residue was dilute with water (100 mL), extracted with EtOAc (100 mL×3), and the organic layers were collected, washed with brine (50 mL), dried over Na2SO4, filtered, and the filtrate was concentrated in vacuo. The residue was purified by flash silica gel chromatography to afford the 331 title compound as an oil. MS (ESI) m/z: 185.8 [M+H+].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39891-13-9, its application will become more common.
Reference:
Patent; Merck Sharp & Dohme Corp.; Han, Yongxin; Achab, Abdelghani; Deng, Yongqi; Fradera, Xavier; Gibeau, Craig; Hopkins, Brett A.; Li, Derun; Liu, Kun; McGowan, Meredeth A.; Sciammetta, Nunzio; Sloman, David; White, Catherine; Zhang, Hongjun; Zhou, Hua; US2019/144433; (2019); A1;,
Pyridine – Wikipedia,
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