Adding a certain compound to certain chemical reactions, such as: 914358-73-9, 5-Bromo-2-methylpyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 914358-73-9, blongs to pyridine-derivatives compound. Computed Properties of C6H7BrN2
To a mixture of 3-amino-5-bromo-2-methylpyridine (8.3 g) and potassium acetate (5.2 g) in chloroform (200 mL) was added acetic anhydride (16.7 mL) at room temperature and the mixture let stirred at room temperature for 3 hours and then heated to reflux for an additional 2 hours, After cooling the mixture to room temperature, was added isoamylnitrite (11.9 mL) and 18-crown-6-ether (1 g) and the mixture heated to reflux for 26 hours. After cooling to room temperature, the mixture was filtered through a plug of Celite. The filtrate was concentrated under reduced pressure to yield a residue that was treated with a suspension of potassium carbonate (10 g) in a mixture of methanol (150 mL) and water (10 mL) at 0 C. for 2 hours. The mixture was concentrated under reduced pressure to yield a residue that was extracted with EA and washed with water. The organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure to give a residue that was triturated with a mixture of DCM and heptane to give 6-bromo-1H-pyrazolo[4,3-b]pyridine (6.85 g, 75% overall yield from 10 g of 5-bromo-2-methyl-3-nitropyridine). MS (ES): M/Z [M+H]=198. 1H NMR: (400 MHz, DMSO-d6): 8.33 (br. s, 2H), 8.57 (d, J=1.7 Hz, 1H), 13.47 (br. s, 1H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,914358-73-9, its application will become more common.
Reference:
Patent; Soll, Mark David; Hir de Fallois, Loic Patrick Le; Huber, Scot Kevin; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Jacobs, Robert Toms; Beck, Brent Christopher; US2010/125089; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem