A new synthetic route of 2-Hydroxyisonicotinaldehyde

At the same time, in my other blogs, there are other synthetic methods of this type of compound,188554-13-4, 2-Hydroxyisonicotinaldehyde, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.188554-13-4, name is 2-Hydroxyisonicotinaldehyde, molecular formula is C6H5NO2, molecular weight is 123.11, as common compound, the synthetic route is as follows.COA of Formula: C6H5NO2

(R)-2-(2-Hydroxy-pyridin-4-yl)-thiazolidine-4-carboxylic acidTo a solution of L-cysteine hydrochloride (402.9 mg, 2.56 mmol) in distilled water (4 mL), potassium acetate (281.7 mg, 2.87 mmol) was added. Once the solids went into solution, methanol (4 mL) was added followed by 2-hydroxy-pyridine-4-carbaldehyde (376.4 mg, 3.06 mmol). Precipitate crashed out of solution within one hour, and the reaction was stirred at ambient temperature overnight. The solvent was removed to give the crude product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,188554-13-4, 2-Hydroxyisonicotinaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; GENELABS TECHNOLOGIES, INC.; WO2008/64218; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem