As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 5-(Trifluoromethyl)pyridin-2-amine
To a solution of phenyl carbonochloridate (1.72 g, 1 1.0 mmol) in dichloromethane (20.0 ml_) was added 5-(trifluoromethyl)pyridin-2-amine (1.62 g, 10.0 mmol) at room temperature under N2. Pyridine (0.870 g, 1 1.0 mmol) was then added to the reaction at 0 C and the resulting mixture stirred for 0.5 h. The reaction mixture was poured into water and extracted with ethyl acetate followed by drying with sodium sulfate. After concentration, the residue was purified with the column chromatography (eluent: dichloromethane: petroleum ether (1 :2)) to afford 1.2 g of the title compound. NMR (400 MHz, DMSO) d 1 1 .24 (s, 1 H), 8.70 (d, J = 0.9 Hz, 1 H), 8.18 (dd, J = 8.9, 2.3 Hz, 1 H), 7.99 (d, J = 8.8 Hz, 1 H), 7.43 (dd, J = 1 1.0, 4.8 Hz, 2H), 7.31 – 7.18 (m, 3H).
With the rapid development of chemical substances, we look forward to future research findings about 74784-70-6.
Reference:
Patent; SYNGENTA CROP PROTECTION AG; SYNGENTA CHINA INVESTMENT COMPANY LIMITED; SCHAETZER, Juergen, Harry; BIGOT, Aurelien; JUNG, Pierre, Joseph, Marcel; STOLLER, Andre; GAGNEPAIN, Julien, Daniel, Henri; HALL, Roger, Graham; RENDINE, Stefano; LU, Long; YANG, Jianzhong; CHEN, Ruifang; (113 pag.)WO2020/30754; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem