As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C6H5F3N2
Example 92:(R)-l-(4-(Trifluoromethyl)phenyl)-N-(6-(trinuoromethyl)pyridin-3-yl)-3,4- dihydroisoquinoline-2(lH)-carboxamide; To a solution of (R)-4-nitrophenyl l-(4-(trifluoromethyl)phenyl)-3,4-dihydroiso- quinoline-2(lH)-carboxylate (70 mg, 158 mumol, example 88) in MeCN (0.5 mL) was added 3-amino-6-(trifluoromethyl)pyridine (77 mg, 475 mumol). The resulting mixture was then subjected to a microwave irradiation at 150 C for 15 min and at 180 C for 15 min. Then, sodium hydride, 60% dispersion in mineral oil (18 mg, 475 mumol) was added and the mixture was stirred at RT for overnight. Then, H2O (0.5 mL) was added and the solvents were removed. The residue was then dissolved in a solution of MeOH and DMSO (1 :1. 1.0 mL). The solution mixture was purified by preparative HPLC (0%-100% MeCN 0.1% TFA/H2O 0.1% TFA) to give the desired product, which was then dissolved in MeOH (1.0 mL). The solution was then washed through PL-HCO3 MP resin (polymerlabs, 200 mg/6 mL tube) and the resin was washed with MeOH (2 x 0.5 mL). The combined washings were then concentrated and dried under vacuum to give the title compound as a yellow solid. MS (ESI, positive ion) m/z: 466 (M+H).
With the rapid development of chemical substances, we look forward to future research findings about 106877-33-2.
Reference:
Patent; AMGEN INC.; WO2009/73203; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem