Electric Literature of 504-24-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 504-24-5, name is 4-Aminopyridine. This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 6 Compounds of the following general formula II-6 may be synthesised, for example, by the following methods. 3-Bromo-4-aminopyridine (1). 4-Aminopyridine (3.0 g, 31.9 mmol) was dissolved in 100 mL of DCM and 60 mL CH3CN. Bromine (5.1 g, 31.9 mmol) was added to this solution dropwise and the solution was stirred for 2 h. Sodium carbonate (6.2 g, 73.8 mmol) was added to the mixture and the reaction was stirred overnight. TLC (EtOAc) analysis of the reaction mixture showed two major spots, the higher running was 4-amino-3,5-dibromopyridine and the lower running one was the desired product (Rf=0.4, EtOAc). The reaction mixture was filtered and the filtrate was concentrated and chromatographed on a minimum amount of silica gel to yield 1.4 g (26%) of the desired product. 1H NMR (CDCl3): delta 8.39 (s, 1H), 8.10 (d, 1H), 6.60 (d, 1H), 4.74 (bs, 2H).
According to the analysis of related databases, 504-24-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Ferraris, Dana V.; Li, Jia-He; Kalish, Vincent J.; Zhang, Jie; US2003/22883; (2003); A1;,
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