Synthetic Route of 884494-54-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 884494-54-6 as follows.
Production Example 21-[(2-Chloro-5-fluoropyridin-4-yl)methyl]-4-methylpiperazine1-Methylpiperazine (0.42 mL), and sodium triacetoxyborohydride (811 mg) were added to a 1% acetic acid-chloroform solution (10 mL) of commercially available 2-chloro-5-fluoroisonicotinaldehyde (555 mg), and the mixture was stirred at room temperature for 5 hours. After addition of a 1 N sodium hydroxide aqueous solution, the reaction mixture was extracted with chloroform, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give a crude product of the title compound (850 mg).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884494-54-6, its application will become more common.
Reference:
Patent; MSD K.K.; US2012/22078; (2012); A1;,
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