Reference of 1072-97-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1072-97-5, name is 5-Bromopyridin-2-amine. A new synthetic method of this compound is introduced below.
Step 1 – Synthesis of 6-bromoimidazo[l,2-] yridine [0251] To a solution of 5-bromopyridin-2-amine (2 g, 11.6 mmol) in ethanol (20 mL) was added 2-chloroacetaldehyde (2.00 g, 25.5 mmol) at room temperature and heated to reflux overnight. The reaction was cooled and concentrated and the resulting solid diluted with saturated sodium bicarbonate and extracted twice with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated to afford 6- bromoimidazo[l,2-a]pyridine as a brown solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1072-97-5, 5-Bromopyridin-2-amine, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas D.; VAN HUIS, Chad A.; MACLEAN, John K.; ANDRESEN, Brian M.; BARR, Kenneth J.; BIENSTOCK, Corey E.; ANTHONY, Neville J.; DANIELS, Matthew; LIU, Yuan; WHITE, Catherine M.; LAPOINTE, Blair T.; SCIAMMETTA, Nunzio; SIMOV, Vladimir; TROTTER, Wesley, B.; LIU, Kun; WO2015/95788; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem