Reference of 55304-75-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 55304-75-1, name is 2,6-Dichloro-3-(trifluoromethyl)pyridine, molecular formula is C6H2Cl2F3N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A suspension of 3-(R)-methyl-1-trityl-piperazine (from Example 4; 7.80 g, 22.9 mmol), 2,6-dichloro-3-trifluoromethylpyridine (4.50 g, 20.8 mmol) and K2CO3 (4.0 g, 29 mmol) in DMSO (100 mL) was stirred at 80 C. over night. A mixture of EtOAc/toluene (50:50; 500 mL) was added to the filtered solution and the mixture were washed three times with water (1 L). The dried (MgSO4) organic phase was concentrated under reduced pressure and the resulting brown oil was dissolved in heptane/EtOAc (90:10) and filtered through a plug (6060 mm) of silica. Slow evaporation of about two thirds of the solvent at reduced pressure afforded light yellow crystals (6.11 g, 56%). Purity 100% (HPLC); mp 209 C. Fragmenting MS analysis supports the stated structure. Anal. (C30H27ClF3N3) C, H, N.
According to the analysis of related databases, 55304-75-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nilsson, Bjorn M.; Ringberg, Erik; US2003/232814; (2003); A1;,
Pyridine – Wikipedia,
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