Electric Literature of 68470-59-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.68470-59-7, name is 2-(Bromomethyl)-6-methylpyridine, molecular formula is C7H8BrN, molecular weight is 186.0491, as common compound, the synthetic route is as follows.
Step B: Preparation of 3 -iodo- 1 -((6-methylpyridin-2-yl)methyl)-4-nitro- 1 H- indazole: To a solution of 3-iodo-4-nitro-lH-indazole (172 mg, 0.596 mmol) in dry DMF (3 mL) under an atmosphere of dry nitrogen was added 2-(bromomethyl)-6-methylpyridine (122 mg, 0.656 mmol) and potassium carbonate (165 mg, 1.19 mmol) with stirring. The mixture was stirred at ambient temperature for 3 days. The reaction mixture was diluted with water (20 mL) and extracted into ethyl acetate. The organic phases were combined, washed with saturated sodium chloride solution, dried over sodium sulfate, filtered and concentrated under reduced pressure. The resulting material was purified using preparative chromatography on silica, eluting with hexane/ethyl acetate (3: 1) to give 3-iodo-l-((6-methylpyridin-2- yl)methyl)-4-nitro-lH-indazole (213 mg).
Statistics shows that 68470-59-7 is playing an increasingly important role. we look forward to future research findings about 2-(Bromomethyl)-6-methylpyridine.
Reference:
Patent; ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; DELISLE, Robert Kirk; HICKEN, Erik James; KENNEDY, April L.; MARESKA, David A.; MARMSATER, Fredrik P.; MUNSON, Mark C.; NEWHOUSE, Brad; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian; WO2012/82689; (2012); A1;,
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