Related Products of 13534-98-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13534-98-0, name is 4-Amino-3-bromopyridine. A new synthetic method of this compound is introduced below.
To a lOOmL reaction flask was added 3-bromo-4-amino-pyridine (1.73 g, lOmmol), p-fluorobenzeneboronic acid (1.68 g, 12 mmol), anhydrous sodium carbonate (1.59 g, 15 mmol), dioxane (20 mL), and water (10 mL) were replaced with nitrogen, The reaction was carried out for about 3 hours. After completion of the reaction, water (20 mL) was added, extracted three times with ethyl acetate (3 X 20 mL), and the mixture was stirred at room temperature The layers were combined, dried over anhydrous sodium sulfate, filtered and steamed off Column 31 (1.738) yield 92% yield. ]
At the same time, in my other blogs, there are other synthetic methods of this type of compound,13534-98-0, 4-Amino-3-bromopyridine, and friends who are interested can also refer to it.
Reference:
Patent; Chengdu Haichuang Pharmaceutical Co., Ltd.; Fan Lei; Du Wu; Li Xinghai; Chen Yuanwei; Xu Kexin; Chen Ke; Zhang Shaohua; Luo Tongchuan; (40 pag.)CN106831556; (2017); A;,
Pyridine – Wikipedia,
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