Application of 156118-16-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 156118-16-0, name is 3-Amino-6-bromo-4-methylpyridine, molecular formula is C6H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 1 ,3-thiazole-4-carbonyl chloride (142 mg) and 6-bromo-4-methyl-3- pyridinamine (18 mg) in DCM (1 mL) was stirred in a Reactivial under nitrogen at 4O0C for 16 h. The reaction mixture was evaporated in vacuo and partitioned between DCM and water. The organic phase was separated and evaporated in vacuo. The crude material was purified using a 4 g silica ISCO cartridge eluting with a gradient of 0-30% EtOAc to give the title compound.MS calcd for (C10H8BrN3OS + H)+ : 298 / 300 MS found (electrospray) : (M+H)+ = 298 / 300
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 156118-16-0, 3-Amino-6-bromo-4-methylpyridine.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/59042; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem