Related Products of 106047-17-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.106047-17-0, name is Methyl 4-(pyridin-4-yl)benzoate, molecular formula is C13H11NO2, molecular weight is 213.23, as common compound, the synthetic route is as follows.
Reference Example 18 Methyl 4-[pyridine-N-oxide-4-yl]-benzoate. To a cooled (0 C.) solution of methyl 4-[pyridin-4-yl]-benzoate (2.1 g, 10 mmol) (reference example 19a) in CH2Cl2 (41 mL) is added m-CPBA (3.4 g, 50-60% technical grade, 10 mmol). The resulting solution is stirred for 1 hour then a further portion of m-CPBA added (1.7 g, 5 mmol). This solution is stirred for 1 hour (temperature held between 5-10 C.) then the reaction mixture poured directly onto a silica gel column. Elution with 10% MeOH/40% EtOAc/50% CH2Cl2 gave 2.0 g of the title compound as a tan solid. 1H NMR (CDC3OD) d 3.94 (s, 3H), 7.90 (m, 4H), 8.14 (d, J=8.5 Hz, 2H), 8.39 (d, J=7 Hz, 2H). MS (EI) m/z 230 (M)+.
Statistics shows that 106047-17-0 is playing an increasingly important role. we look forward to future research findings about Methyl 4-(pyridin-4-yl)benzoate.
Reference:
Patent; Aventis Pharmaceuticals Inc.; US6541505; (2003); B1;,
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