Application of 717106-69-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 717106-69-9, name is Methyl 2-(6-chloropyridin-3-yl)acetate. A new synthetic method of this compound is introduced below.
A mixture of 0.500 g (2.69 MMOL) of Preparatory Compound A and 479 mg (2.69 MMOL) of N-BROMOSUCCINIMIDE in 5 mL of carbon TETRACHLORIDE was treated with 5 mg of azo-bis-isobutyronitrile and was heated at reflux for four hours and was allowed to cool. The mixture was concentrated to dryness and the residue was chromatographed on silica gel (230-400 mesh) using 95/5 DICHLOROMETHANE/ETHYL acetate as eluent to afford 353 mg (50%) of Preparatory Compound S methyl bromo (6-CHLORO- 3-pyridinyl) acetate as an oil ; 1HNMR (CDCI3) 6 8.44 (d, 1H, J= 2.6 HZ), 7.98 (dd, 1 H, J = 8.3 Hz and J = 2.5 Hz), 7.38 (d, 1 H, J = 8.5 Hz), 5.33 (s, 1 H), 3.82 (s, 3H); MS (ES+) m/z 265 ([M+H]+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,717106-69-9, Methyl 2-(6-chloropyridin-3-yl)acetate, and friends who are interested can also refer to it.
Reference:
Patent; DOW AGROSCIENCES LLC; WO2004/57960; (2004); A2;,
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