Application of 52313-50-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 52313-50-5, name is Picolinimidamide. A new synthetic method of this compound is introduced below.
A mixture of N-methyl-4-(4-oxo-1-piperidyl)benzenesulfonamide (0.45 g, 1.67 mmol) andDMFDMA (2 mL) in acetonitrile (8 mL) was heated with stuffing at 90 C for 2 hrs. Theresulting reaction mixture was concentrated in vacuo and the residue was dissolved in EtOH (10 mL). To the solution was added pyridine-2-carboxamidine (0.15 g, 1.23 mmol) and potassium carbonate (034 g, 246 mrnol) successively. After being heated with stirring at 90 C overnight, the resulting reaction mixture was cooled to rt, diluted with water (20 mL) and extracted with EA (20 mL) for three times. The combined organic layer was washed with brine, dried overanhydrous Na2SO4 and concentrated in vacuo. The residue was purified by prep-PLC to give Nmethyl-4- [2- (2-pyridyl)-7 , 8-dihydro-5H-pyrido [4,3-d]pyrimidin-6-yl]benzenesulfonamide (7 mg). ?H NMR (400MHz, CDC13): oe 8.87 (d, 1H), 8.80 – 8.70 (m, 1H), 8.53 (d, 1H), 7.89 (dt, 1H), 7.80 (d, 2H), 7.44 (ddd, 1H), 7.06 – 6.97 (m, 2H), 4.63 (s, 2H), 3.86 (t, 2H), 3.32 (t, 2H), 2.67 (s, 3H). MS obsd. (ESIj [(M+H)?i: 382.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,52313-50-5, Picolinimidamide, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Min; YANG, Song; (208 pag.)WO2016/107832; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem