In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115170-40-6, name is 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 115170-40-6
In a microwave vial are combined l-ieri-butyl-2-(5-methoxy-2-pyrazol-l-yl-phenyl)-5- (4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-benzimidazole (285 mg, 0.60 mmol), 5-bromo-2,3-dihydro-lH-pyrrolo[2,3-b]pyridine (100 mg, 0.50 mmol), potassium carbonate (140 mg, 1.0 mmol), and bis(di-ieri-butyl(4- dimethylaminophenyl)phosphine)dichloropalladium(II) (53 mg, 0.08 mmol) in toluene (3.0 mL) and water (0.30 mL). The reaction vial is sealed and stirred at 100 C for 4 hours in an oil bath. After this time the reaction is cooled and poured into water. The product is extracted into EtOAc (2x). The combined organics are dried (MgS04), filtered and concentrated. Purification via flash chromatography (12g silica gel, 0-5% MeOH/ CH2C12) affords the title compound (40 mg, 17%). LCMS (ESMS): m/z 465.20 (M++l)
The synthetic route of 115170-40-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHEN, Zhidong; HAO, Ming-Hong; LIU, Weimin; LO, Ho-Yin; LOKE, Pui Leng; MAN, Chuk, Chui; MORWICK, Tina, Marie; NEMOTO, Peter, Allen; TAKAHASHI, Hidenori; TYE, Heather; WU, Lifen; WO2011/68821; (2011); A1;,
Pyridine – Wikipedia,
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