Application of 779345-37-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 779345-37-8, name is 5-Fluoro-2-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.
A solution of 1-azaadamantan-4-ol N-borane complex (1 eq.) and a heteroaryl halide (1.1 eq.) in anhydrous DMF (0.5-1 M) was chilled to between -20 and 0 C and treated with sodium hydride (1.5 equiv; 95%, Aldrich). After 15 minutes, the cooling bath was removed and the mixture was allowed to warm to room temperature. When 1 -azaadamantan-4-ol N-borane complex was consumed as determined by TLC analysis (generally 1-2 hours), the mixture was diluted with water and stirred for 1 hour. The resulting solid product was collected by filtration, washed with water, and dried under reduced pressure to afford the desired product; (4s)-4-(6-Nitropyridin-3-yloxy)-1-azatricyclo[3.3.1.13,7]decane N-borane complex Prepared from the product of Example 10A (419 g, 2.51 mmol) and 5-fluoro-2-nitropyridine (420 mg, 2.9 mmol; see US Patent Appl. 20040209886) according to Method A: 1H NMR (300 MHz, chloroform-D) delta ppm 1.68 – 1.78 (m, 2 H), 2.07 (s, 1 H), 2.20 – 2.35 (m, 4 H), 3.19 – 3 34 (m, 6 H), 4.74 (t, J=3.4 Hz, 1 H), 7.42 (dd, J=9.0, 2.9 Hz, 1 H), 8.26 – 8.31 (m, 2 H). MS (DCI/NH3) m/z= 290 (M+H)+
According to the analysis of related databases, 779345-37-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBOTT LABORATORIES; WO2008/58096; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem